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  • COSENTYX® for psoriasis arthritis

    What is COSENTYX® and how does it work?

    COSENTYX® is a biologic therapy that contains the active substance secukinumab, which is a fully-human monoclonal antibody. Monoclonal antibodies are proteins that recognize and bind specifically to certain proteins in the body. A protein called ‘IL-17A’ is present at increased levels in diseases such as psoriatic arthritis. COSENTYX® works by neutralizing the activity of IL-17A. COSENTYX® reduces the signs and symptoms of psoriatic arthritis.

    How and when do I take COSENTYX®?

    The recommended dose of COSENTYX® is 150 mg for psoriatic arthritis. Your doctor may have prescribed a dose of 300 mg if you have moderate to severe plaque psoriasis in addition to psoriatic arthritis or if you did not respond well to medicines called tumor necrosis factor (TNF) blockers or continue to have active psoriatic arthritis. Your COSENTYX® is administered as a subcutaneous self-injection using the COSENTYX® SensoReady® pen or COSENTYX® pre-filled syringe. If your prescribed dose of COSENTYX® is 150 mg, you will administer 1 injection of COSENTYX®. If your prescribed dose of COSENTYX® is 300 mg, you will administer 2 injections.

    Before beginning your treatment, you will be fully trained to ensure you are at ease with injecting yourself. If not, a caregiver, friend, or family member can also be trained to administer your injections. You and your doctor can decide on this together.

    At the start of your treatment, you will take your COSENTYX® injections at Weeks 0, 1, 2, 3 and 4, followed by monthly maintenance dosing.

    Always use COSENTYX® as your doctor has discussed with you. Check with your doctor, nurse, or pharmacist if you are not sure. Detailed instructions on how to inject COSENTYX® using the COSENTYX® pre-filled syringe and COSENTYX® SensoReady® pen are part of the XPOSE® starter kit provided to you when you begin your treatment.

    For detailed instructions on how to inject COSENTYX®, see
    “My Injection Steps card” available in the “My Resources” section of this website.

    Important safety information to read before starting COSENTYX®


    You should store the COSENTYX® SensoReady® pen sealed in its outer box to protect it from light. It should be kept in the refrigerator between 2°C and 8°C. DO NOT FREEZE.

    If necessary, the pre-filled syringe and the SensoReady pen may be stored unrefrigerated for a single period of up to 4 days at room temperature, not above 30°C. Discard the pre-filled syringe or SensoReady pen after 4 days if left unrefrigerated.

    If you accidentally inject more COSENTYX® or sooner than instructed, inform your doctor immediately. In the event of drug overdose, contact your doctor, a member of your health care team, your local hospital emergency department, or regional Poison Control Centre immediately, even if there are no symptoms.

    If you have forgotten to inject a dose of COSENTYX®, take the dose when you remember and return to your regular schedule. Then talk to your doctor to discuss when you should inject the next dose.

    • - You currently have an infection or if you have long-term or repeated infections
    • - You have tuberculosis. Your doctor should check for tuberculosis before starting treatment
    • - You ever had an allergic reaction to latex. The needle cap on the COSENTYX® SensoReady® pen and pre-filled syringe contains a derivative of latex
    • - You have Crohn’s disease or ulcerative colitis
    • - You had a recent vaccination or if you will receive a vaccination during treatment with COSENTYX®

    Do not use COSENTYX® if you had a severe allergic reaction to secukinumab or any of the other ingredients of COSENTYX®. If you think you may be allergic, talk to your doctor, and ask for advice before using COSENTYX®. Do not take COSENTYX® if you have any signs of infection or an active tuberculosis infection unless you are instructed to by your health care provider. COSENTYX® is not recommended for children and adolescents (under 18 years of age) because it has not been studied in this age group.

    Talk to your doctor before using COSENTYX®:

    • - If you are pregnant, think that you may be pregnant or are planning to have a baby
    • - COSENTYX® is not recommended during pregnancy unless the benefits clearly outweigh the potential risks
    • - If you are breastfeeding or plan to breastfeed
    • - It is not known if COSENTYX® passes into your breast milk

    As with all medicines, patients treated with COSENTYX® may experience side effects. Most of the side effects with COSENTYX® are mild to moderate. The most common side effects include:

    • - Upper respiratory tract infections with symptoms such as sore
    • - Throat and stuffy nose (nasopharyngitis, rhinitis)
    • - Cold sores (oral herpes)
    • - Diarrhea
    • - Itchy rash (urticaria)
    • - Runny nose (rhinorrhea)

    The above is not a complete list of side effects; for more complete information, refer to the Consumer Information leaflet available here.

    Talk to your doctor or pharmacist immediately if you get any of these symptoms during your COSENTYX® treatment.

    You have worsening symptoms or develop new symptoms of stomach pain or diarrhea.

    Signs or symptoms of a potentially serious infection. These may include:

    • - Fever, flu-like symptoms, muscle aches, night sweats
    • - Feeling tired or short of breath; cough which will not go away
    • - Warm, red and painful skin, or a painful skin rash with blisters
    • - Burning when passing water

    Signs or symptoms of an allergic reaction. These may include:

    • - Chest tightness, difficulty breathing or swallowing
    • - Low blood pressure, which can cause dizziness or light-headedness
    • - Swelling of the face, lips, mouth or throat

    Do not use COSENTYX® if you have any signs of infection or an allergic reaction unless you are instructed to by your health care provider.

    STOP using COSENTYX® and seek medical help immediately if you experience any of the following, which are signs of an allergic reaction:

    • - Difficulty breathing or swallowing
    • - Swelling of the face, lips, tongue or throat
    • - Severe itching of the skin, with a red rash or raised bumps

    You should always tell your doctor about any other medications you are taking before starting COSENTYX®.

    • - Talk to your doctor if you have recently had or are going to have a vaccination. You should not receive certain types of vaccines (live vaccines) while using COSENTYX®